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ESO-OECI Course on Cancer Molecular Pathobiology in the Clinics: Highlights

Not eligible for ESCO credits

18.04.2012  -  20.04.2012

Cluj Napoca, Romania

COURSES AND SEMINARS

Cancer genetics / genomics

Description

Chairs: I. Berindan Neagoe, RO - R. Buiga, RO - A. Irimie, RO - A. Paradiso, IT - J. Reis Filho, UK - P. Riegman, NL - P. Sloan, UK


This conference will look at the new and exciting field of cancer biology and treatment. New trends in personalized medicine open different overviews of pathology and molecular biology as linked for the patient benefit.

Implementing clinical use of personalized diagnostics can stratify patients, give molecular classification of disease, determine the likelihood of occurrence, and recommend the best course of treatment.  These approaches promise to reduce costs in healthcare, improve treatment, and have the potential to provide consumer-driven access to health information. Technologies have to be evaluated for research and clinical use, and approaches for turning these discoveries into viable business models will be highlighted.

The course shall represent a premiere in this part of Europe bringing together key speakers and personalities in the most challenged fields in cancer diagnostics and treatment. A long term cooperation between OECI, ESO and the local organizer, The Oncology Institute Ion Chiricuta of Cluj Napoca, will assure an excellent scientific atmosphere for all specialists interested in understanding and learning the hot topics of the new cancer  era.

A special session shall be accorded to virtual microscopy slides evaluation as a practical approach for pathologists and specialists in the field.

All of you who consider that the event can line your career please join us at our course. The list shall cover a maximum number of 200 international participants.

We hope to have you as our guests next spring , learning together, working together in the remarkably beautiful old city of Cluj Napoca with its old  history from the Roman Empire and Middle Age adventures - a place to come again .

Ioana Berindan Neagoe
Course Chairman


LEARNING OBJECTIVES 
Participants will acquire knowledge on:

• Molecular mechanisms of cancer for clinical evaluation
• Pathology versus molecular biology for cancer diagnosis and response to treatment : Specific role and value
• Molecular oncology tests
• The next generation technologies underlying molecular diagnostics today
• New trends in clinical trials



MAIN TOPICS
• Role of EGFR  in different cancers
• HPV related malignancies ( priority for head and neck)
• Molecular analysis of archive tissues: Next generation technologies and molecular diagnostic laboratories, genomic screening and diagnostic
• Molecular mechanisms and signaling pathways as hallmarks of cancer
• Gene regulation including chromatin structure and remodeling, transcription, RNA processing and stability, and translation relevant to oncogenesis
• Role of characterized stem cells in tumor validation
• Cell death pathways (both apoptotic and non-apoptotic)
• Proteomics and functional genomics for clinical evaluation
• Scan pathology
• Implementation of virtual microscope slides in pathobiology of cancer
• Developing of molecular clinical trials – molecules in clinical development


An intensive and interactive course developed and sustained by the cooperation of OECI, ESO and Oncology Institute Cluj Napoca

General information

FURTHER INFORMATION
For further information, please  visit:
Cancercourse2012@iocn.ro
Or contact  :
Ass. Prof. Ioana Berindan Neagoe
Scientific Director
Oncology Institute Ion Chiricuta, Cluj Napoca, Romania
Mobile +40 743111800
www.iocn.ro
E mail: ioanaberi@iocn.ro ; ioananeagoe29@yahoo.com


VENUE
City Plaza Hotel
9-13 Sindicatelor Street
Cluj-Napoca, RO 400029
Romania


TRAVEL GRANTS
ESO is offering ten international TRAVEL GRANTS of 250 Euros, and ten national TRAVEL GRANTS of 50 euro for young participants less than 35 years interested in Molecular Pathobiology.
To be eligible for a TRAVEL GRANT please complete the registration form with an abstract for a poster presentation, and send a CV in English together with a list of free publications at OECI_ESO@iocn.ro.

Faculty list


FACULTY
P. Achimas
, RO
O. Balacescu, RO
I. Berrindan Neagoe, RO
R. Buiga, RO
S.J.  Christophe, FR
T.E. Ciuleanu, RO
A. Cucuianu, RO
A. Eniu, RO
B. Fetica, RO
R. Gatti, US
J. Green, UK
K. Henry, UK
A. Irimie, RO
G. Kontogeorgos, GR
V. Lazar, FR
R. Mader, AT
E. Medico, IT
A. Paradiso, IT
N. Rao, US
J. Reis Filho, UK
P. Riegman, NL
J. Sehouli, DE
P. Sloan, UK
S. Srivastava, US
G. Stanta, IT
P. Terrier, FR
G. Viale, IT
C. Zielinski, AT

Programme


18 April

  

Arrivals

  8:30

Registration and welcome
A. Irimie and J. Reis Filho

9:00

INTRODUCTION

 

The role of modern pathology
J. Reis Filho, UK

 

Cancer biobanks in Europe
P. Riegman, NL

 

New biomarker discovery process
A. Paradiso,IT
 Personalised medicine: the goal of our days?
P. Achimas, RO
 Molecular diagnostic in cancer
I. Berindan Neagoe, RO

10:00

Coffee break
FIRST SESSION - METHODOLOGICAL ASPECTS
Chairs: V. Lazar, FR - B. Fetica, RO 

10:30

The value of high throughoutput technologies in diagnostic and pragnostic evaluation of solid tumors
V. Lazar, FR 
10:50Searching for the gold standard in HER/2NEU testing in breast cancer
B. Fetica, RO 
11:10 Gene expression profiling for predicting treatment response in cervical cancer
O. Balacescu, RO 
11:30Circulation tumor cells in cancer therapy management
R. Buiga, RO 
11:50Radiobiology in cancer treatment
V. Cernea, RO 
12:10Posters presentation 
12:30Discussion 
13:00Lunch 
SECOND SESSION - TRANSLATIONAL APPROACHES 
Chairs: T.E. Ciuleanu, RO - A. Paradiso, IT  
14:00Vitalpropagation of colorectal cancer tissues to study molecular markers and targets in colorectal cancer
E. Medico, IT 
14:20Personalised therapy for lung cancer: from benchside to bed
T.E. Ciuleanu, RO 
14:40Banking paraffin tissues - The ideal for personalized medicine clusterization
G. Stanta, IT 
15:00

Myelodysplastic syndromes (MDS) and acute myeloid leukemia with myelodysplasia related changes (MRC-AML)
Pathogenitic and therapeutics aspects 
A. Cucuianu, RO

15:20Poster presentations
15:50Discussion 
16:15Coffee break 
 ROUND TABLE - BIOBANKS IN DISCOVERING AND VALIDATION BIOMARKERS PROCESS
Chair: P. Riegman, NL
Participants: A. Eniu, RO - V. Lazar, FR - R. Mader, AT - A. Paradiso, IT

 

19 April

THIRD SESSION - METHODOLOGY IN CLINICS
Chairs: R. Gatti, US - I. Neagoe, RO - N. Rao, US

 8:40

Current role of cytogenetics and fish in laboratory diagnostics
N. Rao, US

9:00

Translating molecular cancer biology into therapeutic concept
R. Mader, AT

 9:20

The link between molecular biology and the clinic: principles and practice
K. Henry, UK

9:40

Target therapy in cancer
I. Neagoe, RO

10:00

Development of drugs to induce ribosomal readthrough of nonsense mutations in genetic disease and cancer
R. Gatti, US

10:20

Poster presentations

10:40

Coffee break
FOURTH SESSION - CLINICAL ASPECTS
Chairs: A. Eniu, RO - J. Sehouli, DE

11:00

Clinical updates in colon cancer
S.J. Christophe, FR
11:20Clinical updates in ovarian cancer
J. Sehouli, DE 
11:40The real benefits of targeted therapy in breast cancer: examples of neoadjuvant treatment
A. Eniu, RO 
12:00

Lecture:
Biomarkers to minimize pathological uncertainties in cancer detection and diagnosis. the NCI's early detection research experience
S. Srivastava, US 

13:00Lunch 
FIFTH SESSION - CLINICAL PATHOLOGICAL CORRELATIONS
Chairs: K. Henry, FR - R. Buiga, Ro - J. Green, UK
14:30Prise en charge des sarcomes. Apport de l'immunohistochismie et del la biologie moleculaire
P. Terrier, FR 
14:30New horizons in diagnostic and management of endocrine tumors
G. Kontogeorgos, GR 
15:10Clinical updates in ovarian cancer: role of clinical trials in personalised medicine
J. Green, UK 
15:30Coffee break 
16:00Translational research in head and neck cancer
P. Sloan, UK 
16:30Poster and travel awards 

17:00 

Conclusions
OECI as a network for future collaboration 
 

The Romanian reality for future collaboration
I. Neagoe, RO

 

20 April

SCAN PATHOLOGY SESSION (FOR PRE-REGISTERED PATHOLOGISTS)
Chairman and contributors with one case each (8 cases)

 9:00CEGOG - The environment for developing molecular evaluation in clinical trials
C. Zielinski, AT

9:30

G. Stanta, IT
G. Viale, IT
P. Terrier, FR
G. Kontogeorgeos, GR
10:15Coffee break 

10:45 

C. Henry, FR
G. Kontogeorgeos, GR
R. Buiga, RO
B. Fetica, RO

12:15Closing ceremony