Belfast, United Kingdom
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Chairs: M. Clarke, UK - P. Johnston, UK
Scientific Co-ordinator: G. Griffith, UK
AIMS AND OBJECTIVES
This 5-day Masterclass will take participants through the key steps in preparing a systematic review of research in cancer that they can use to guide decisions about treatment, guidelines or the design of new research. The Masterclass will help the participants to strengthen the design of the review they are interested in and learn generic skills that they can apply to other systematic reviews. These skills will cover the following key features for any systematic review:
• Formulation of the question
• Choice of inclusion and exclusion criteria, and selection of outcomes
• Development and implementation of a search strategy
• Application of inclusion and exclusion criteria, and appraisal of quality and risk of bias in potentially eligible studies
• Data extraction
• Planning and conduct of meta-analyses, including subgroup and sensitivity analyses
• Exploration of heterogeneity
• Drawing conclusions and discussing implications for practice and research
Participants will bring a topic of their choosing to the Masterclass, and these topics will form the basis of the problem-based approach to learning that will be used throughout the course. The course will be divided into eight sessions covering different aspects of the systematic review process. Each day will include one or two formal lectures from experts, as well as group discussions that draw on the knowledge of the expert. The group discussions will be a mixture of whole-group work and small-group work, in which participants will be divided into parallel groups to tackle specific issues relating to their review questions. These groups will be facilitated by experienced systematic reviewers from the Faculty, and will conclude with feedback presented by one member of each group.
Participants will be provided with a bibliography containing up to three key readings for each session. The Masterclass will be run entirely in English, and fluency is necessary for admission.
THE MASTERCLASS IS:
• A 5-day residential educational event
• Full immersion
• Clinically oriented
In collaboration with:
|The Masterclass is an |
ESMO labeled meeting:
European School of Oncology
Via Turati, 29
20121 Milan, Italy
Fax: +39 02 85464545
Programme and Organisation
Ph: +39 02 85464525
Ph: +39 02 85464529
The Accreditation Council of Oncology in Europe (ACOE) and the European Accreditation Council for Continuing Medical Education (EACCME) have acknowledged the quality of the scientific programme and its educational value. The “ESO Masterclass on Systematic Reviews in Cancer Care, Guidelines and Research” has been assigned 24 European Continuing Medical Education Credits (ECMEC).
Through an agreement between the European Union of Medical Specialists and the American Medical Association, physicians may convert EACCME credits to an equivalent number of AMA PRA Category 1 Credits™. Information on the process to convert EACCME credit to AMA credit can be found at www.amaassn.org/go/internationalcme.
Furthermore, the Masterclass has been accredited with 9, cat. 1 ESMO-MORA points.
F. Alderdice, Queen’s University Belfast, UK
C. Cardwell, Queen’s University Belfast, UK
M. Clarke, Queen’s University Belfast, UK
E. Gargon, University of Liverpool, Liverpool, UK
S. Hopewell, Centre for Statistics in Medicine, Oxford, UK
P. Johnston, Queen’s University Belfast, UK
M. Lodge, International Network for Cancer Treatment and Research, Oxford, UK
L. Murray, Queen’s University Belfast, UK
L. Stewart, Centre for Reviews and Dissemination, York, UK
C. Tudur-Smith, University of Liverpool, UK
|Welcome speech by Professor Patrick Johnston and Professor Mike Clarke|
|Session 1: Formulating the question and eligibility criteria|
Lecture: What makes a good question for a systematic review
Group work: Each participant will outline the topic they have brought to the Masterclass and formulate the appropriate question that could be answered by a systematic review.
Lecture: Determining the inclusion and exclusion criteria for a systematic review
Group work: Each participant will determine the inclusion and exclusion criteria for their systematic review.
|End of session|
Session 2: Outcome selection
Lecture: The role of core outcome sets in systematic reviews
Group work: Each participant will choose the outcomes they would like to report in their systematic review, covering both benefits and harms; and distinguish which of these would be primary and secondary outcomes.
Session 3: Search strategy
|Lecture: How to develop a search strategy for a systematic review |
M. Lodge, UK
Group work: Each participant will identify bibliographic databases and other sources of trials (e.g. prospective registries) that are likely to be high yield for their systematic review and explore the appropriate text words and index terms to use in a search of at least one of these databases.
End of session
Session 4: Determining eligibility and data extraction
Lecture: Developing a data extraction form and assessing the retrieved articles
Group work: Each participant will develop their plan for assessing the retrieved articles.
Group work: Each participant will prepare an outline for the data extraction form for their systematic review.
|Session 5: Study quality and risk of bias|
|14:00||Lecture: Assessing risk of bias in a systematic review |
S. Hopewell, UK
|15:30||Group work: Each participant will consider the key areas of study quality and bias for their systematic review and the ways in which these might be assessed.|
|18:00||End of session|
Session 6: Statistical analyses Part 1
Lecture: Meta-analysis 1
|Group work: Each participant will develop a statistical analysis plan for their review, including the methods to be used to analyse the primary outcomes and any subgroup or sensitivity analyses.|
Session 7: Statistical analyses Part 2
Lecture: Meta-analysis 2
Group work: Each participant will continue to develop a statistical analysis plan for their review, including the methods to be used to investigate statistical heterogeneity.
Lecture: Meta-analysis of observational data
|Group work: Each participant will consider how they might develop a statistical analysis plan for a review of epidemiological data.|
|End of session|
Session 8: Heterogeneity, strength and relevance of the evidence
Lecture: Heterogeneity in systematic reviews
Group work: Each participant will revisit the key sources of heterogeneity across the studies in their review, including those relating to the types of intervention, participant, study designs and outcome measures.
Lecture: What does your review mean for practice and research?
Group work: Each participant will consider how they might communicate the strength and findings of their review.
Close of Masterclass