Innovation in Radio-Oncology Course

Chairs: J. Bernier, CH - F.A. Calvo, ES
Host Chair: A. Kuten, IL
Scientific Coordinators: Z. Symon, IL - Y. Belkacemi, FR
Local Committee: A. Kuten, IL - R.L. Pfeffer, IL - R. Bar-Deroma, IL - T. Katzman, IL - F. Atrash, IL


This 3-day ESO course is dedicated to clinical, technical and biological innovations in the management of cancer with emphasis on radiation oncology. Hot topics such as single and hypo-fractionated RT, stereotactic brain and body RT, focal RT, particle RT, radiobiology of hypo-fractionation, SBRT and particle RT, the scientific basis of immunotherapy, combination of RT and immunotherapy and targeted therapies, prediction of response and complications, will be discussed. In addition, local Israeli high-tech achievements and innovations in basic and applied cancer research will be presented.


LEARNING OBJECTIVES
• Update the knowledge in radiobiology, hypofractionated, stereotactic brain and body RT, focal RT, particle RT, the scientific basis of immunotherapy and combined RT - immunotherapy and targeted therapies.
• Become aware of innovative strategies in radiation oncology and combined modality therapy of cancer
• Learn how to incorporate the innovative strategies in daily practice

Held in collaboration with
With the support of
ESTRO recommended course

ORGANISING SECRETARIAT
European School of Oncology
Via Turati 29, 20121 Milan, Italy
Francesca Marangoni
E-mail: fmarangoni@eso.net
Phone: +39 02 85464527


LOCAL ORGANISER AND REGISTRATION
I.M. Knasim Ltd
Tel Aviv, Israel
Ayelet Levy
knasim@imknasim.co.il
Tel: +972-3-6081520 - Fax: +972-3-6081522


VENUE
Leonardo City Tower Hotel
Zisman Shalom St 14, Ramat Gan, Tel Aviv, Israel
http://leonardo-city-tower.hotel-rn.com


OFFICIAL LANGUAGE
The course will be held in English and no translation will be provided.


INSURANCE
The organisers bear no responsibility for untoward events in relation to the participation in the course. Participants are advised to take out their own personal and travel insurance.


BADGE
The name badge is the only official evidence of registration and should be worn at all times during the Conference


ACKNOWLEDGEMENT
ESO wishes to express its appreciation to the following companies for having supported the course through unrestricted educational grants:

FACULTY
D. Alezra, Chaim Sheba Medical Center and Sackler School of Medicine, Tel Aviv, IL
A. Alon, Radiation Oncology, Davidoff Oncology Institute, Rabin Med Ctr, Petach Tiqva, IL
U. Amit, Sheba Medical Center and Sackler School of Medicine, Tel Aviv, IL
F. Atrash, Dept of Radiation Therapy, Augusta Victoria Hospital, East Jerusalem, IL
R. Bar-Deroma, Dept. of Oncology, Rambam Health Care Campus, Haifa, IL
Y. Belkacemi, Dept. of Radiaton Oncology, Hopitaux Universitaires Henri Mondor, Creteil, FR
M. Ben David, Chaim Sheba Medical Center and Sackler School of Medicine, Tel Aviv, IL
S. Ben-Haim, Nuclear Medicine, Chaim Sheba Medical Center and Sackler School of Medicine, Tel Aviv, IL
R. Ben Yoseph, Rambam Healthy Care Campus, Faculty of Medicine, Technion, Haifa, IL
J. Bernier, Dept. of Radio Oncology, Swiss Medical Network, Genolier Clinic, Genolier, CH
D.T. Blumenthal, Tel Aviv Medical Center, Tel Aviv, IL
F.A. Calvo, Hospital General Universitario Gregorio Maranon, Madrid, ES
L. Domachevsky, Dept. of Radiology and Nuclear Medicine, Assuta Medical Centers, Tel Aviv, IL
E. Even-Sapir, Nuclear Medicine, Tel Aviv Med Ctr, and Sackler School of Medicine, Tel Aviv, IL
E. Gez, Radiation Oncology, Tel Aviv Medical Center, Tel Aviv, IL
J. Gligorov, Dept. of Medical oncology, Tenon Hospital, Paris, FR
T. Katzman, Dept. Radiation Oncology, Chaim Sheba Medical Center, Tel Hashomer, IL
A. Kuten, Dept. of Oncology, Italian Hospital Haifa, Haifa, IL
Y.R. Lawrence, Chaim Sheba Medical Center and Sackler School of Medicine, Tel Aviv, IL
R. Leibowitz-Amit, Dept. of Medical Oncology, Oncology Institute and Cancer Research Center, Tel Hashomer, IL
D. Levin, Dept. of Radiotherapy, Assuta Medical Centers, Tel Aviv, IL
A.J. Lomax, Dept. of Radiation Therapy, Paul Scherrer Institute, Villigen, CH
O. Luxenburg, Director of Medical Technologies and Infrastructure Administration at Ministry of Health, Jerusalem, IL
M. Marash, P-Cure Ltd – Patient Centric Proton Therapy, Lod, IL
G. Markel, Chaim Sheba Medical Center and Sackler School of Medicine, Tel Aviv, IL
W. Mermershtain, Department of Oncology, University of the Negev, Beer-Sheva, IL
R. Miralbell, Serv. De Radio-Oncologie, Hopitaux Universitaires, Geneva, CH
M. Ozsahin, Centre Hospitalier Universitaire Vaudois, Lausanne, CH
F. Peccatori, Scientific Director, European School of Oncology (ESO), Milan, IT
R. Pfeffer, Assuta Medical Centers, Tel Aviv, IL
M. Pruschy, Laboratory for Molecular Radiobiology, Dept. Radiation Oncology University Hospital, Zurich, CH
G. Rechavi, Sheba Medical Center, Djerassi Chair in Oncology, Tel Aviv, IL
E. Robinson, Israel Cancer Israel Cancer Association, Givatayim, IL
R. Schneider, Dept of Radiation Therapy, Paul Scherrer Institute, Villigen, CH
Z. Symon, Dept. Radiation Oncology, Chaim Sheba Medical Center, Tel Aviv, IL
R. Spiegelmann, Sheba medical Center and Assuta Hospitals, Ramat Gan, Tel Aviv, IL
Y. Tova, Assuta Medical Centers, Tel Aviv, IL
T. Tzuk, Rambam Health Care Campus, Faculty of Medicine, Technion, Haifa, IL
N. Weizman, Dept. of Radiation Oncology, Chaim Sheba Medical Center, Ramat Gan, IL
M. Wygoda, Radiation Oncology, Hadassah Medical Center, Hebrew University, Jerusalem, IL
L. Zach, Chaim Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, IL
A. Zigler, High Intensity Laser Lab and Chair of Physics, Hebrew University of Jerusalem, IL
A. Ziv, MSR – Israel Center for Medical Simulation, Chaim Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, IL
M. Ziv, Israel Cancer Association, Givatayim, IL

1 MARCH

8:00		Welcome and opening address A. Kuten, IL - J. Bernier, CH - F.A. Calvo, ES - Z. Symon, IL - J. Gligorov, FR - O. Luxenburg, IL - M. Ziv, IL - W. Mermershtain, IL F. Peccatori, IT - E. Robinson, IL
MULTIMODALITY IMAGING FOR MODERN RADIOTHERAPY Chair: L. Domachevsky, IL
8:30		Why MRI is needed in radiotherapy planning and re-irradiation L. Zach, IL
9:00		Role of MRI planning of prostate cancer R. Miralbell, CH
9:30		Role of PET CT/PET MRI for target volume definition (Breast, lung, cervix, lymphoma) S. Ben-Haim, IL
9:50		Role of PET MRI M. Ozsahin, CH
10:00		From molecular imaging to targeted therapy: The story of PSMA and PRRT E. Even-Sapir, IL
10:45		Coffee break
MANAGING MOTION IN RADIOTHERAPY Chair: R. Bar-Deroma, IL
11:00		Managing motion in radiotherapy: principles and practice D. Levin, IL
12:00		Innovation - beyond breath hold - improving geometry by respiratory intervention: CPAP and other strategies N. Weizman, IL
12:30		Lunch
STEREOTACTIC BODY RADIATION THERAPY Chair: A. Alon, IL
13:30		Overview of SBRT trials for oligometastases R. Pfeffer, IL
14:15		Prostate SBRT and focal RT: Early results from European multicentric study R. Miralbell, CH
15:00		SBRT in pain management: New horizons Y.R. Lawrence, IL
15:30		Coffee break
BRAIN METASTASIS: NEW PARADIGMS Chair: T. Tzuk, IL
16:00		SRS vs WBRT vs no RT, a multidisciplinary approach and overview of trials L. Zach, IL
16:45		Radiosurgery for multiple brain metastasis: Current technologies R. Pfeffer, IL - R. Spiegelman, IL
17:15		TKI, Braf and other "biologicals" for brain metastasis: How to use with radiotherapy? D.T. Blumenthal, IL
17:45		Case presentation and panel discussion (all of the above speakers)

2 MARCH

PARTICLE THERAPY: 2016 AND BEYOND (PART I) Chair: M. Ozsahin, CH
8:30		Overview of proton facilities: What is commercially available and what is in the pipeline? A.J. Lomax, CH
9:30		Radiobiology of low-LET protons and photons: Early reports on differential responses mechanisms M. Pruschy, CH
10:00		Present and future indications for PT R. Schneider, CH
10:45		Coffee break
PARTICLE THERAPY: 2016 AND BEYOND (PART II) Chair: E. Gez, IL
11:00		Innovation: P cure M. Marash, IL
11:15		Innovation: “Tabletop” laser generated protons A. Zigler, IL
11:30		Innovation: Creating “bragg peak” like electrons D. Alezra, IL
11:45		Focused ultrasound (Insightech) R. Pfeffer, IL
12:00		Panel: New technologies in RT J. Bernier, CH - R. Miralbell, CH - R. Schneider, CH - Z. Symon, IL - R. Pfeffer, IL - R. Bar Deroma, IL - A.J. Lomax, CH M. Ozsahin, CH
12:30		Lunch
NEW HORIZONS IN PERSONALIZED MEDICINE AND IMMUNOTHERAPY FOR CANCER (PART I) Joint session with Israel Cancer Research Society Chair: J. Gligorov, FR
13:30		The role of RNA epigenetics in cancer G. Rechavi, IL
14:15		Overview of state-of-the-art immunotherapy (including Ceacam 1) G. Markel, IL
15:15		Understanding the toxicities of modern immunotherapy R. Leibowitz-Amit, IL
15:45		Coffee break
NEW HORIZONS IN PERSONALIZED MEDICINE AND IMMUNOTHERAPY FOR CANCER (PART II) Chair: F. Atrash, IL
16:00		Immunotherapy agents and radiotherapy: Results and ongoing clinical trials Abscopal effect of RT - from the lab to clinical practice U. Amit, IL
16:45		Bio-dosimetry and personalized radiotherapy Y.R. Lawrence, IL

3 MARCH

RADIOBIOLOGY OF HYPOFRACTIONATED RT AND SBRT Chair: Y.R. Lawrence, IL
8:30		Radiobiology of hypofractionation and SBRT: cellular and tissue level M. Pruschy, CH
9:15		Hypofractionation for breast cancer: Tumor control and normal tissue complications M. Ben David, IL
9:45		Hypofractionation for prostate cancer: Tumor control and normal tissue complications M. Wygoda, IL
10:15		Coffee break
APBI AND INTRAOPERATIVE RT Chair: Y. Tova, IL
10:30		IORT for primary breast cancer: A critique Y. Belkacemi, FR
11:00		Intraoperative electron boost in polyvalent indications: 30 years’ results and innovative technologies F.A. Calvo, ES
RT IN THE MEDITERRANEAN AREA AND EDUCATION Chair: R. Ben Yoseph, IL
11:30		Radiation oncology - need and availability around the Mediterranean area Y. Belkacemi, FR
11:45		The power and the impact of simulation in medical education for the next generation A. Ziv, IL
12:15		A new approach for radiotherapy education in small and medium size countries: Moving forward from IEAA  train the-trainers T. Katzman, IL
12:30		Closing ceremony
12:45		Lunch