Oncogenetics

Programme description

Oncogenetics is a discipline at the crossroads of research, direct clinical impact (informing therapeutic strategies such as PARP inhibitors, personalised surveillance, prophylactic surgery), and human support of patients and their families. It requires constant reflection on the management of uncertainty and optimal decision-making, since not all cancers — even in young patients or families with multiple cases — have a constitutional genetic explanation.

• Oncogenetics consultations: investigation of genetic predisposition in index cases (constitutional analyses), pre-symptomatic diagnosis in relatives, and follow-up coordination for patients with multi-organ predisposition syndromes (Cowden, Li-Fraumeni…)
• Oncogenetics MDTs: two dedicated meetings for complex cases — one on digestive cancer predispositions (Lynch and Lynch-like syndromes, familial polyposis), and one on gynaecological cancer predispositions (HBOC)
• Molecular Tumour Boards (RCP moléculaires): bridging tumour molecular analyses with personalised therapeutic strategies