CCI4EU - How to optimize molecular diagnostics in practice?

CCI4EU - 10th online course

CCI4EU - How to optimize molecular diagnostics in practice?

CCI4EU - 10th online course


Chairs

Laura Mezquita, ES; Richard Rosenquist Brandell, SE
Introduction:
CCI4EU (Comprehensive Cancer Infrastructures for the European Union) is a European project aiming to help Member States and Associated Countries improve or develop their existing or future Comprehensive Cancer Infrastructures (CCIs), by helping develop their research & innovation-related capacities.
 
This course is one of 10 online training courses organised within the project to help countries develop an effective comprehensive infrastructure and widen the reach of this grant. The topic of this online course is How to optimize molecular diagnostics in practice?

Course aim:
Next-generation sequencing technologies have revolutionized the field of molecular diagnostics in cancer. This course will explore the impact of molecular diagnostics on cancer diagnosis, prognosis, and treatment prediction, as well as the implications of identifying germline pathogenic variants. We will also examine how clinical decision support tools can assist Molecular Tumor Boards and inform clinical decision-making. Additionally, emerging technologies in precision cancer medicine will be discussed, along with best practice examples from precision cancer medicine programs.

Target audience:
Physicians/clinicians, researchers, management, coordinators, patients and patient advocates  

Course delivery:
This online course was held live on 4 November 2025 via this webpage. The entire course has been recorded and will remain available as on-demand material.
To access the on-demand materials (after the live streaming), participants must register to the course, login to the e-ESO platform and click on the play buttons inside the course programme.  The online course includes two cases (see information below for the Call for Cases).

Call for Cases:
Objective - To promote active and multidisciplinary learning through the analysis and discussion of clinical scenarios that reflect current challenges in the clinical application of biomarkers, targeted therapies, personalized medicine, and molecular data interpretation.

*The selected cases has been presented to the Experts during the live course on 4 November 2025
*Each case was allotted 10 minutes of time (including presentation and salient questions for the Experts).

Submission Requirements

  • Language: English
  • Format: Use the official template provided (attached - on righthand side of screen).
  • Recommended length: 1–2 pages per section
  • Required case content: Title, Authors and affiliation, Five Keywords, Introduction (clinical context/relevance), Case Presentation, Discussion (key elements of precision medicine), Conclusion, Optional Figure

Topics:
Section 1 (Molecular diagnosis in patients with hematological and solid tumours)
Section 2 (Impact of germline variants in cancer diagnostics)

Submission and Deadline:

  • Deadline for submission: CALL EXTENDED until Friday, 10 October 2025
  • Please note that you must be available to participate in the live course on 4 November 2025.
  • Format: Template (attached - on righthand side of screen)
  • Submission email: sgoldman@eso.net
  • Subject line: “CCIEU 2025 Clinical Case – [First Author’s Name]”

Evaluation and Selection:

  • Cases have been reviewed by the course’s scientific and teaching committee.
  • Evaluation criteria included clinical quality, clarity, educational relevance, and the incorporation of precision medicine concepts.
  • Selected cases have been chosen for interactive discussion during the course. 
Official language:
The course was held in English. Translations are not provided, but English subtitles can be activated and transcriptions can be automatically translated using free online tools.
 
Registration:
Registration to the course is free but mandatory. 
 
Certificate of attendance:
Participants (both live and on-demand) will be issued a certificate of attendance once they have completed a minimum attendance of 75% of the entire course. An online evaluation questionnaire must be completed in order to receive the certificate that will be issued by email. The evaluation questionnaire will appear in the right-hand column of the course page when participants have completed the course.
 
Organising secretariat
Sarah Goldman: sgoldman@eso.net
Francesca Marangoni: fmarangoni@eso.net
04/11/2025 12:29

Live Streaming


04/11/2025 12:30

Welcome

Laura Mezquita (ES) Richard Rosenquist Brandell (SE)

04/11/2025 12:35

Molecular diagnosis in patients with hematological and solid tumours

12:35

Moving from cytogenetics to WGS in diagnostics of hematological malignancies

Lucia Cavelier (SE)
12:50

Comprehensive genomic profiling in clinical routine; does it make sense for all patients?

Etienne Rouleau (FR)
13:05

Treatment-agnostic tumors - how to organize the molecular diagnosis

Cristina Teixido (ES)
13:20

Interactive Clinical Case Session - Case Presentation

Cesar Abel Centurion Rodriguez (PE)
13:35

Live Panel Session

Lucia Cavelier (SE) Laura Mezquita (ES) Richard Rosenquist Brandell (SE) Etienne Rouleau (FR) Cristina Teixido (ES)

04/11/2025 13:55

Impact of germline variants in cancer diagnostics

13:55

Shifting from single gene test to comprehensive genomic profiling: implications on germline variant detection

Teresa Ramon y Cajal (ES)
14:10

Clinical implications of germline findings ontreatment selection and cancer prevention

Elena Castro (ES)
14:25

How to manage incidental pathogenic germline variants in somatic testing

Bianca Tesi (SE)
14:40

Interactive Clinical Case Session - Case Presentation

Ahmed Mohsen Aboelfotoh Elalfy (EG)
14:55

Live Panel Discussion

Laura Mezquita (ES) Teresa Ramon y Cajal (ES) Richard Rosenquist Brandell (SE) Bianca Tesi (SE)

04/11/2025 15:15

Break


04/11/2025 15:25

New tools optimising diagnosis and management

15:25

Advances in Liquid Biopsy for Early Diagnosis and Disease Monitoring

Javier Hernández Losa (ES)
15:40

Clinical Decisions for Optimizing Molecular Diagnosis for Patients with Solid Tumours

David Tamborero (SE)
15:55

Proteogenomics and other -omics technologies

Janne Lehtiö (SE)
16:10

Live Panel Discussion

Javier Hernández Losa (ES) Janne Lehtiö (SE) Laura Mezquita (ES) Richard Rosenquist Brandell (SE) David Tamborero (SE)

04/11/2025 16:25

Precision Medicine Programs in Cancer Centers

16:25

Precision medicine program in a comprehensive cancer center: experience & organization (first example)

Christophe Massard (FR)
16:40

Precision medicine program in a comprehensive cancer center: experience & organization (second example)

Albrecht Stenzinger (DE)
16:55

How is the organization of a Molecular Tumor Board in clinical practice

Hege G. Russnes (NO)
17:10

Live Panel Discussion

Christophe Massard (FR) Laura Mezquita (ES) Richard Rosenquist Brandell (SE) Hege G. Russnes (NO) Albrecht Stenzinger (DE)

04/11/2025 17:25

Take Home Messages

Laura Mezquita (ES) Richard Rosenquist Brandell (SE)
Ahmed Mohsen Aboelfotoh Elalfy profile photo
Ahmed Mohsen Aboelfotoh Elalfy

Oncology Center Mansoura University, Medical Oncology Dpt., Mansoura, EG

Albrecht Stenzinger profile photo
Albrecht Stenzinger

Heidelberg University Hospital, Institute of Pathology, Heidelberg, DE

Bianca Tesi profile photo
Bianca Tesi

, , ,

Cesar Abel Centurion Rodriguez profile photo
Cesar Abel Centurion Rodriguez

Instituto Nacional Enfermedades Neoplásicas Del Peru (inen), Medicina Oncologica, Lima, PE

Christophe Massard profile photo
Christophe Massard

Gustave Roussy Institute, Department of Therapeutic Innovation and Early Stage Trials, Villejuif, FR

Cristina Teixido profile photo
Cristina Teixido

Hospital Clinic Barcelona, Somatic Molecular Diagnostics Biomedical Diagnostic Center, Barcelona, ES

David Tamborero profile photo
David Tamborero

Karolinska Institutet, SciLifeLab, Stockholm, SE

Elena Castro profile photo
Elena Castro

Hospital Universitario 12 de Octubre, Oncology Dept., Madrid, ES

Etienne Rouleau profile photo
Etienne Rouleau

Institut Gustave Roussy, Genetic Dept., Villejuif, FR

Hege G. Russnes profile photo
Hege G. Russnes

Oslo University Hospital, Department of Pathology, Oslo, NO

Janne Lehtiö profile photo
Janne Lehtiö

Karolinska Institutet, Department of Oncology and Pathology, Stockholm, SE

Javier Hernández Losa profile photo
Javier Hernández Losa

Hospital Universitario Vall d´Hebron, Dept of Pathology, Barcelona, ES

Laura Mezquita profile photo
Laura Mezquita

University of Barcelona, Laboratory of Translational Genomics and Targeted Therapies in Solid Tumors, IDIBAPS, Barcelona, ES

Lucia Cavelier profile photo
Lucia Cavelier

Karolinska Institutet, Department of Molecular Medicine and Surgery, Stockholm, SE

Richard Rosenquist Brandell profile photo
Richard Rosenquist Brandell

Karolinksa Institutet, Clinical Genetics and Genomics, Solna,

Teresa Ramon y Cajal profile photo
Teresa Ramon y Cajal

Hospital Clinic of Barcelona, Medical Oncology, Barcelona, ES